Olfactory Cleft Length: A Possible Risk Factor for Persistent Post-COVID-19 Olfactory Dysfunction.

INTRODUCTION: To date, little is known about predisposing factors for persistent COVID-19-induced olfactory dysfunction (pCIOD). The objective was to determine whether olfactory cleft (OC) measurements associate with pCIOD risk. MATERIAL AND METHODS: Three subgroups were recruited: group A included patients with pCIOD, group B included patients without olfactory dysfunction following SARS-CoV-2 infection (ntCIOD), and group C consisted in controls without past history of SARS-CoV-2 infection (noCOVID-19). Olfactory perception threshold (OPT) and visual analog scale for olfactory impairment (VAS-olf) were obtained. OC measurements were obtained through computed tomography scans. Results were subsequently compared. RESULTS: A total of 55 patients with a mean age of 39 ± 10 years were included. OPT was significantly lower in pCIOD patients (group A: 4.2 ± 2.1 vs. group B: 12.3 ± 1.8 and group C: 12.2 ± 1.5, p < 0.001). VAS-olf was significantly higher in pCIOD (group A: 6 ± 2.6 vs. group B: 1.7 ± 1.6 and group C: 1.6 ± 1.5, p < 0.001). OC length was significantly higher in group A (42.8 ± 4.6) compared to group B (39.7 ± 3.4, p = 0.047) and C (39.8 ± 4, p = 0.037). The odd of pCIOD occurring after COVID-19 infection increased by 21% (95% CI [0.981, 1.495]) for a one unit (mm) increase in OC length. The odd of pCIOD occurring was 6.9 times higher when OC length >40 mm. CONCLUSION: Longer OC may be a predisposing factor for pCIOD. This study is expected to encourage further research on OC morphology and its impact on olfactory disorders.

A decreased trajectory of loneliness among Brazilians aged 50 years and older during the COVID-19 pandemic: ELSI-Brazil.

This study aimed to estimate prevalence of loneliness among older Brazilian adults over the first seven months of the COVID-19 pandemic and to identify the predictors of loneliness trajectories. Pre-pandemic data derived from face-to-face interviews of participants of the 2019-2020 Brazilian Longitudinal Study of Aging (ELSI-Brazil), which is a nationally representative study of community-dwelling individuals aged 50 years and over. Pandemic data were based on three rounds of telephone interviews among those participants, conducted from May to October 2020. Loneliness was measured by a single-item question, considering those who had at least two repeated measures. Explanatory variables included depression, living alone, leaving home in the last week, and virtual connectedness in the last month. Mixed-effects logistic regression was used to estimate odds ratios with their 95% confidence intervals (95%CI) and to investigate loneliness trajectories and their predictors. In total, 5,108 participants were included. The overall prevalence of loneliness in the pre-pandemic period was 33.1% (95%CI: 29.4-36.8), higher than the pandemic period (round 1: 23.6%, 95%CI: 20.6-26.9; round 2: 20.5%, 95%CI: 17.8-23.5; round 3: 20.6%, 95%CI: 17.1-24.6). A significant interaction (p ≤ 0.05) was evidenced only between depression and time; participants with depression showed a greater reduction in loneliness levels. Although loneliness levels in Brazil have decreased during the pandemic, this pattern is not present for all older adults. Individuals with depression had a more significant reduction, probably due to feeling closer to their social network members during the stay-at-home recommendations.

Agro-residual biomass and disposable protective face mask: a merger for converting waste to plastic-fiber fuel via an integrative carbonization-pelletization framework

Incineration and landfilling offer possibilities for addressing high-rate management of COVID-waste streams. However, they can be costly and environmentally unsustainable. In addition, they do not allow to convert them to fuels and chemicals as waste-to-energy and waste-to-product technologies. Therefore, we analyzed whether integrating hydrothermal carbonization (HTC) and pelletization can allow converting the surgical face mask (SFM) and biomass to composite plastic-fiber fuel (CPFF). We blended the plastic material and corncob, peanut shell, or sugarcane bagasse at the proportion of 50:50 (%, dry mass basis) for HTC. We performed the thermal pretreatment of blends in an autoclaving reactor at 180 °C and 1.5 MPa. Then we pelletized the hydrochars in a presser machine at 200 MPa and 125 °C. By analyzing the evidence from our study, we recognized the viability of combining the SFM and agricultural residues for CPFF from comparable technical features of our products to standards for premium-grade wood pellets. For instance, the elemental composition of their low-meltable ash was not stoichiometrically sufficient to severely produce slagging and fouling in the equipment for thermal conversion. Although they contained synthetic polymers in their structures, such as polyethylene from filter layers and nylon from the earloop, they emitted CO and NOx below the critical limits of 200 and 500 mg m−3, respectively, for occupational safety. Therefore, we extended the knowledge on waste-to-energy pathways to transform SFM into high-quality hybrid fuel by carbonization and pelletization. Our framework can provide stakeholders opportunities to address plastic and biogenic waste in the context of a circular economy. Supplementary Information The online version contains supplementary material available at 10.1007/s13399-022-03285-4.

Postoperative inverted intercostal hernia incidentally detected by chest computed tomography in a patient with COVID-19.

Inverted intercostal hernias are uncommon, and even more so when comprised of soft tissue instead of lung parenchyma in the postoperative context. This report demonstrates a case in with such a hernia was diagnosed through chest multidetector computerized tomography in a 48-year-old woman who presented to the emergency room with respiratory symptoms and tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). She had positive surgical history for left lower lobectomy with bronchoplastic procedure and mediastinal lymphadenectomy, due to an endobronchial typical carcinoid tumor a few years ago. Therefore, it is important for radiologists to be aware of the imaging characteristics of inverted intercostal hernias, to avoid diagnostic errors.

The Ensembl COVID-19 resource: ongoing integration of public SARS-CoV-2 data.

The COVID-19 pandemic has seen unprecedented use of SARS-CoV-2 genome sequencing for epidemiological tracking and identification of emerging variants. Understanding the potential impact of these variants on the infectivity of the virus and the efficacy of emerging therapeutics and vaccines has become a cornerstone of the fight against the disease. To support the maximal use of genomic information for SARS-CoV-2 research, we launched the Ensembl COVID-19 browser; the first virus to be encompassed within the Ensembl platform. This resource incorporates a new Ensembl gene set, multiple variant sets, and annotation from several relevant resources aligned to the reference SARS-CoV-2 assembly. Since the first release in May 2020, the content has been regularly updated using our new rapid release workflow, and tools such as the Ensembl Variant Effect Predictor have been integrated. The Ensembl COVID-19 browser is freely available at https://covid-19.ensembl.org.

Poor Sleep Quality and Daytime Sleepiness in Health Professionals: Prevalence and Associated Factors.

This study aimed to examine the prevalence rates of poor quality sleep and daytime sleepiness in health professionals and their association with socioeconomic, lifestyle, and anthropometric factors and psychosocial work conditions. This cross-sectional study was performed with health professionals from various public and private hospitals in Rio Verde, Goiás, Brazil. Daytime sleepiness and sleep quality were assessed using the Epworth Sleepiness Scale and the Pittsburgh Sleep Quality Index, respectively. The variables were analyzed using multiple hierarchical Poisson regression in the statistical package Stata version 13.0. A total of 244 health professionals participated in this study (women, 78.28%). The rates of abnormal daytime sleepiness and poor sleep quality were 50.41% (n = 123) and 55.74% (n = 136), respectively. Reduced physical activity was associated with poor sleep quality (prevalence ratio (PR) = 1.32; 95% confidence interval (CI) 1.02-1.70, p = 0.035). Age between 20 and 29 years (PR = 2.59; 95% CI 1.37-4.91, p = 0.021) and 30 and 49 years (PR = 2.09; 95% CI 1.12-3.91, p = 0.021), as well as excessive alcohol consumption (PR = 1.29; 95% CI 1.01-1.66, p = 0.048), were risk factors for daytime sleepiness. Conversely, adequate bodyweight (PR = 0.52; 95% CI 0.33-0.82, p = 0.005) was considered a protective factor. The present findings suggest high rates of abnormal daytime sleepiness and poor sleep quality among healthcare professionals. We emphasize the importance of physical activity, adequate weight, and healthy habits for better quality sleep and reduced daytime sleepiness.

Loneliness and social disconnectedness in the time of pandemic period among Brazilians: evidence from the ELSI COVID-19 initiative.

Objectives: This study aimed at estimating the pre-pandemic and pandemic prevalence of loneliness and investigating the association of loneliness with social disconnectedness during social distancing strategies in the time of the COVID-19 pandemic period.Methods: We used data from the ELSI COVID-19 initiative with participants from the Brazilian Longitudinal Study of Aging (ELSI-Brazil), which comprised 4,431 participants aged 50 years and over. Loneliness (hardly ever/some of the time/often) was assessed by the question "In the past 30 days, how often did you feel alone/lonely?". Social disconnectedness included information on social contacts through virtual talking (i.e. telephone, Skype, WhatsApp, or social media) and outside-home meetings with people living in another household. Covariates included sociodemographic and health related characteristics. Multinomial logistic regression models were used to estimate odds ratios (OR) with their 95% confidence interval (CI).Results: The overall prevalence of loneliness during the pandemic was 23.9% (95% CI 20.7-27.5); lower than in the pre-pandemic period (32.8%; 95% CI 28.6-37.4). In the pandemic period, 20.1% (95% CI 16.9-23.6) reported some of the time feeling lonely and 3.9% (95% CI 3.1-4.8) reported often feeling lonely. In the fully adjusted model, virtual talking disconnectedness (OR=1.67; 95% CI 1.09-2.56) was positively associated with some of the time feeling lonely and outside-home disconnectedness (OR=0.33; 95% CI 0.18-0.60) was negatively associated with often feeling lonely.Conclusion: Individuals with virtual talking disconnectedness and without outside-home disconnectedness are at higher risk of loneliness during the time of COVID-19 pandemic. Stimulating virtual talking connectedness might have the potential to diminish loneliness despite steep outside-home disconnectedness.

Relationship between work before the epidemic and having gone out to work during the epidemic among participants in the Brazilian Longitudinal Study of Aging: results of the ELSI-COVID-19 initiative. / Relação entre trabalho antes da epidemia e ter saído para trabalhar durante esse período entre participantes do Estudo Longitudinal da Saúde dos Idosos Brasileiros: resultados da iniciativa ELSI-COVID-19.

The objective of this study was to examine the prevalence of going out to work during the COVID-19 epidemic, and the factors associated with this, among adults aged 50 years and over who were in paid employment before its onset. We used data from the second wave of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), conducted through face-to-face interviews between August 2019 and March 2020 (before the onset of the epidemic), in a representative national sample of adults aged 50 and over, and data obtained through telephone interviews carried out among the same participants (ELSI-COVID-19 initiative), conducted between May 26 and June 8, 2020 (during the epidemic). The analyses were based on odds ratios (OR) estimated by logistic regression. The participants' mean age was 59.9 years (SD = 6.5). The prevalence of going out to work in the previous seven days was 38.4% (95%CI: 31.3-46.1), 50.2% among men and 25.1% among women (formal work, self-employment, and informal work). The results showed that among men, the likelihood of going out to work was lower among those aged 60 to 69 years compared to those aged 50 to 59 years (OR = 0.27; 95%CI: 0.15-0.48). Among women, the likelihood was lower among those who were self-employed (OR = 0.28; 95%CI: 0.12-0.64) or in informal employment before the epidemic (OR = 0.25; 95%CI: 0.09-0.69), compared to those in formal employment. One of the hypotheses to explain this association is that women in informal employment were more likely to be dismissed, and that self-employed women have stopped working during the epidemic.

O objetivo do estudo foi examinar a prevalência e fatores associados a ter saído para trabalhar durante a epidemia da COVID-19, entre adultos com 50 anos ou mais que exerciam trabalho remunerado antes do seu início. Foram utilizados dados da segunda onda do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil), conduzida por meio de entrevista face a face, entre agosto de 2019 e março de 2020 (antes do início da epidemia), em amostra nacional representativa de adultos com 50 anos ou mais, e dados obtidos por meio de entrevistas telefônicas realizadas entre esses participantes (iniciativa ELSI-COVID-19), conduzidas entre 26 de maio e 8 de junho de 2020 (durante a epidemia). As análises foram baseadas nas odds ratios (OR) estimadas pela regressão logística. A média de idade dos participantes foi 59,9 anos (DP = 6,5). A prevalência de ter saído para trabalhar nos sete dias anteriores foi de 38,4% (IC95%: 31,3-46,1), 50,2% entre os homens e 25,1% entre as mulheres (trabalho formal, por conta própria e informal). Os resultados mostraram que, entre os homens, a chance de ter saído para trabalhar foi menor entre aqueles de 60 a 69 anos em comparação com aqueles de 50 a 59 anos (OR = 0,27; IC95%: 0,15-0,48). Entre as mulheres, a probabilidade de ter saído para trabalhar foi menor entre aquelas que trabalhavam por conta própria (OR = 0,28; IC95%: 0,12-0,64) ou tinham vínculo informal de trabalho antes da epidemia (OR = 0,25; IC95%: 0,09-0,69), em comparação àquelas com vínculo formal de trabalho. Uma das hipóteses para explicar essa associação é que as mulheres com vínculo informal tenham sido dispensadas e aquelas que trabalhavam por conta própria tenham deixado de trabalhar durante a epidemia.

El objetivo del estudio fue examinar la prevalencia y factores asociados a haber salido para trabajar durante la epidemia de la COVID-19, entre adultos con 50 años o más, que ejercían trabajo remunerado antes del inicio de la misma. Se utilizaron datos de la segunda fase del Estudio Brasileño Longitudinal del Envejecimiento (ELSI-Brasil), llevada a cabo mediante una entrevista cara a cara, entre agosto de 2019 y marzo de 2020 (antes del inicio de la epidemia), en una muestra nacional representativa de adultos con 50 años o más, y datos obtenidos por medio de entrevistas telefónicas realizadas entre estos participantes (iniciativa ELSI-COVID-19), realizadas entre el 26 de mayo y 8 de junio de 2020 (durante la epidemia). Los análisis se basaron en las odds ratios (OR) estimadas por regresión logística. La media de edad de los participantes fue 59,9 años (DP = 6,5). La prevalencia de haber salido para trabajar durante los siete días anteriores fue de un 38,4% (IC95%: 31,3-46,1), 50,2% entre hombres y un 25,1% entre las mujeres (trabajo formal, por cuenta propia e informal). Los resultados mostraron que, entre los hombres, la oportunidad de haber salido a trabajar fue menor entre aquellos con edades comprendidas entre los 60 a 69 años, en comparación con aquellos de 50 a 59 años (OR = 0,27; IC95%: 0,15-0,48). Entre las mujeres, la probabilidad de haber salido a trabajar fue menor entre aquellas que trabajaban por cuenta propia (OR = 0,28; IC95%: 0,12-0,64) o tenían un vínculo laboral informal antes de la epidemia (OR = 0,25; IC95%: 0,09-0,69), en comparación con aquellas con un vínculo laboral formal. Una de las hipótesis para explicar esta asociación es que las mujeres con un vínculo informal fueron dispensadas del servicio y aquellas que trabajaban por cuenta propia hayan dejado de trabajar durante la epidemia.

COVID-19 and acute pulmonary embolism: what should be considered to indicate a computed tomography pulmonary angiography scan?

The full spectrum of COVID-19 is still emerging, although several studies have highlighted that patients infected with the novel coronavirus can potentially develop a hypercoagulable state. However, several aspects related to the incidence and pathophysiology of the association between COVID-19 and pulmonary embolism are not well established. Here, we present a case of a patient with COVID-19 who developed acute pulmonary embolism. Clinical and laboratory data and findings of non-enhanced CT indicate possibility of acute pulmonary embolism, and support the decision to proceed with computed tomography pulmonary angiography that can objectively identify filling defects in pulmonary arterial branches.

Relationship between work before the epidemic and having gone out to work during the epidemic among participants in the Brazilian Longitudinal Study of Aging: results of the ELSI-COVID-19 initiative

Resumo: O objetivo do estudo foi examinar a prevalência e fatores associados a ter saído para trabalhar durante a epidemia da COVID-19, entre adultos com 50 anos ou mais que exerciam trabalho remunerado antes do seu início. Foram utilizados dados da segunda onda do Estudo Longitudinal da Saúde dos Idosos Brasileiros (ELSI-Brasil), conduzida por meio de entrevista face a face, entre agosto de 2019 e março de 2020 (antes do início da epidemia), em amostra nacional representativa de adultos com 50 anos ou mais, e dados obtidos por meio de entrevistas telefônicas realizadas entre esses participantes (iniciativa ELSI-COVID-19), conduzidas entre 26 de maio e 8 de junho de 2020 (durante a epidemia). As análises foram baseadas nas odds ratios (OR) estimadas pela regressão logística. A média de idade dos participantes foi 59,9 anos (DP = 6,5). A prevalência de ter saído para trabalhar nos sete dias anteriores foi de 38,4% (IC95%: 31,3-46,1), 50,2% entre os homens e 25,1% entre as mulheres (trabalho formal, por conta própria e informal). Os resultados mostraram que, entre os homens, a chance de ter saído para trabalhar foi menor entre aqueles de 60 a 69 anos em comparação com aqueles de 50 a 59 anos (OR = 0,27;IC95%: 0,15-0,48). Entre as mulheres, a probabilidade de ter saído para trabalhar foi menor entre aquelas que trabalhavam por conta própria (OR = 0,28;IC95%: 0,12-0,64) ou tinham vínculo informal de trabalho antes da epidemia (OR = 0,25;IC95%: 0,09-0,69), em comparação àquelas com vínculo formal de trabalho. Uma das hipóteses para explicar essa associação é que as mulheres com vínculo informal tenham sido dispensadas e aquelas que trabalhavam por conta própria tenham deixado de trabalhar durante a epidemia. Resumen: El objetivo del estudio fue examinar la prevalencia y factores asociados a haber salido para trabajar durante la epidemia de la COVID-19, entre adultos con 50 años o más, que ejercían trabajo remunerado antes del inicio de la misma. Se utilizaron datos de la segunda fase del Estudio Brasileño Longitudinal del Envejecimiento (ELSI-Brasil), llevada a cabo mediante una entrevista cara a cara, entre agosto de 2019 y marzo de 2020 (antes del inicio de la epidemia), en una muestra nacional representativa de adultos con 50 años o más, y datos obtenidos por medio de entrevistas telefónicas realizadas entre estos participantes (iniciativa ELSI-COVID-19), realizadas entre el 26 de mayo y 8 de junio de 2020 (durante la epidemia). Los análisis se basaron en las odds ratios (OR) estimadas por regresión logística. La media de edad de los participantes fue 59,9 años (DP = 6,5). La prevalencia de haber salido para trabajar durante los siete días anteriores fue de un 38,4% (IC95%: 31,3-46,1), 50,2% entre hombres y un 25,1% entre las mujeres (trabajo formal, por cuenta propia e informal). Los resultados mostraron que, entre los hombres, la oportunidad de haber salido a trabajar fue menor entre aquellos con edades comprendidas entre los 60 a 69 años, en comparación con aquellos de 50 a 59 años (OR = 0,27;IC95%: 0,15-0,48). Entre las mujeres, la probabilidad de haber salido a trabajar fue menor entre aquellas que trabajaban por cuenta propia (OR = 0,28;IC95%: 0,12-0,64) o tenían un vínculo laboral informal antes de la epidemia (OR = 0,25;IC95%: 0,09-0,69), en comparación con aquellas con un vínculo laboral formal. Una de las hipótesis para explicar esta asociación es que las mujeres con un vínculo informal fueron dispensadas del servicio y aquellas que trabajaban por cuenta propia hayan dejado de trabajar durante la epidemia. Abstract: The objective of this study was to examine the prevalence of going out to work during the COVID-19 epidemic, and the factors associated with this, among adults aged 50 years and over who were in paid employment before its onset. We used data from the second wave of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), conducted through face-to-face interviews between August 2019 and March 2020 (before the onset of the epidemic), in a representative national sample of adults aged 50 and over, and data obtained through telephone interviews carried out among the same participants (ELSI-COVID-19 initiative), conducted between May 26 and June 8, 2020 (during the epidemic). The analyses were based on odds ratios (OR) estimated by logistic regression. The participants'mean age was 59.9 years (SD = 6.5). The prevalence of going out to work in the previous seven days was 38.4% (95%CI: 31.3-46.1), 50.2% among men and 25.1% among women (formal work, self-employment, and informal work). The results showed that among men, the likelihood of going out to work was lower among those aged 60 to 69 years compared to those aged 50 to 59 years (OR = 0.27;95%CI: 0.15-0.48). Among women, the likelihood was lower among those who were self-employed (OR = 0.28;95%CI: 0.12-0.64) or in informal employment before the epidemic (OR = 0.25;95%CI: 0.09-0.69), compared to those in formal employment. One of the hypotheses to explain this association is that women in informal employment were more likely to be dismissed, and that self-employed women have stopped working during the epidemic.

COVID-19 and acute pulmonary embolism: what should be considered to indicate a computed tomography pulmonary angiography scan?

The full spectrum of COVID-19 is still emerging, although several studies have highlighted that patients infected with the novel coronavirus can potentially develop a hypercoagulable state. However, several aspects related to the incidence and pathophysiology of the association between COVID-19 and pulmonary embolism are not well established. Here, we present a case of a patient with COVID-19 who developed acute pulmonary embolism. Clinical and laboratory data and findings of non-enhanced CT indicate possibility of acute pulmonary embolism, and support the decision to proceed with computed tomography pulmonary angiography that can objectively identify filling defects in pulmonary arterial branches.

Cerebellopontine Angle Lipoma Manifesting as Trigeminal Neuralgia

The pandemic of coronavirus SARS-CoV-2 disease affected Northern Italy, spreading from the Bergamo province to the entire country. During reorganization of our emergency department to support patients presenting with co-ronavirus SARS-CoV-2 disease, we aimed to evaluate whether children play a role in intrahospital spread of the infection. (J Pediatr 2020;222:231-5).